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ChemicalBook--->CAS DataBase List--->2411890-36-1

2411890-36-1

2411890-36-1 Structure

2411890-36-1 Structure
IdentificationBack Directory
[Name]

4(3H)-Quinazolinone, 8-methyl-7-(1-propyn-1-yl)-2-[(2-pyrimidinylthio)methyl]-
[CAS]

2411890-36-1
[Synonyms]

PARP11 inhibitor ITK7 (ITK7)
4(3H)-Quinazolinone, 8-methyl-7-(1-propyn-1-yl)-2-[(2-pyrimidinylthio)methyl]-
[Molecular Formula]

C17H14N4OS
[MOL File]

2411890-36-1.mol
[Molecular Weight]

322.38
Chemical PropertiesBack Directory
[Boiling point ]

528.4±60.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

Solid
[pka]

-0.35±0.33(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC50 value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization[1].
[Biological Activity]

ITK7 is a cell penetrantpotent and selective inhibitor of PARP11 mono-ADP-ribosylation (MARylation) activity.
[References]

[1] Kirby, Ilsa T et al. A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity. Cell chemical biology vol. 25,12 (2018): 1547-1553.e12. DOI:10.1016/j.chembiol.2018.09.011
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