| Identification | Back Directory | [Name]
Thalidomide-O-PEG4-Boc | [CAS]
2411681-87-1 | [Synonyms]
Thalidomide-O-PEG4-Boc
Thalidomide-O-PEG4-t-butyl ester | [Molecular Formula]
C28H38N2O11 | [MDL Number]
MFCD32670312 | [MOL File]
2411681-87-1.mol | [Molecular Weight]
578.61 |
| Chemical Properties | Back Directory | [Boiling point ]
717.3±60.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3(Predicted) | [form ]
Viscous Liquid | [pka]
10.70±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Thalidomide-O-PEG4-t-butyl ester, is synthesized intermediate that incorporates the Thalidomide based cereblon ligand and PEG space used in PROTAC technology. | [Uses]
Thalidomide-O-PEG4-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. | [IC 50]
Cereblon | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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