| Identification | Back Directory | [Name]
LY-3499446 | [CAS]
2409131-50-4 | [Synonyms]
LY-3499446
2-Propen-1-one, 1-[4-[7-(2-amino-7-fluoro-4-benzothiazolyl)-6-chloro-8-fluoro-4-quinazolinyl]-1-piperazinyl]-
1-[4-[7-(2-amino-7-fluoro-1,3-benzothiazol-4-yl)-6-chloro-8-fluoro-quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one | [Molecular Formula]
C22H17ClF2N6OS | [MDL Number]
MFCD32862450 | [MOL File]
2409131-50-4.mol | [Molecular Weight]
486.92 |
| Hazard Information | Back Directory | [Uses]
KRASG12C IN-13 (LY3499446) is a potent KRAS G12C inhibitor. KRASG12C IN-13 is promising for research of advanced solid tumors including non-small cell lung cancer and colorectal cancer[1]. | [References]
[1] Nagasaka M, et al. KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne? Cancer Treat Rev. 2020 Mar;84:101974. DOI:10.1016/j.ctrv.2020.101974 |
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