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ChemicalBook--->CAS DataBase List--->2407516-83-8

2407516-83-8

2407516-83-8 Structure

2407516-83-8 Structure
IdentificationBack Directory
[Name]

cGAMP disodium
[CAS]

2407516-83-8
[Synonyms]

cGAMP disodium
[Molecular Formula]

C20H25N10NaO13P2
[MOL File]

2407516-83-8.mol
[Molecular Weight]

698.41
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

White to off-white
[Water Solubility ]

Soluble to 10 mM in water
Hazard InformationBack Directory
[Uses]

cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
[Biological Activity]

cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including serum anti-PA neutralizing and anti-PA SIgA responses in airway secretions[1][2].
[in vivo]

cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].

Animal Model:Female C57BL/6 (H-2b) mice 6-8 weeks old[2]
Dosage:5 μg
Administration:Nostril mucosal adjuvant
Result:Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
[IC 50]

Human Endogenous Metabolite
[storage]

Store at -20°C
[References]

[1]. Wright TA, et al. Second messengers and divergent HD-GYP phosphodiesterases regulate 3’,3’-cGAMP signaling. Mol Microbiol. 2020;113(1):222-236.
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