| Hazard Information | Back Directory | [Uses]
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. | [Biological Activity]
cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including serum anti-PA neutralizing and anti-PA SIgA responses in airway secretions[1][2]. | [in vivo]
cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2]. | Animal Model: | Female C57BL/6 (H-2b) mice 6-8 weeks old[2] | | Dosage: | 5 μg | | Administration: | Nostril mucosal adjuvant | | Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.
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| [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C | [References]
[1]. Wright TA, et al. Second messengers and divergent HD-GYP phosphodiesterases regulate 3’,3’-cGAMP signaling. Mol Microbiol. 2020;113(1):222-236. |
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https://www.invivochem.cn/ |
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