| Identification | Back Directory | [Name]
Phenanthro[1,2-b]furan-7,10,11(6H)-trione, 1-[(acetyloxy)methyl]-6,6-dimethyl- | [CAS]
2379527-72-5 | [Synonyms]
IDO1/TDO-IN-1
Phenanthro[1,2-b]furan-7,10,11(6H)-trione, 1-[(acetyloxy)methyl]-6,6-dimethyl- | [Molecular Formula]
C21H16O6 | [MOL File]
2379527-72-5.mol | [Molecular Weight]
364.35 |
| Hazard Information | Back Directory | [Uses]
IDO1/TDO-IN-1 (30) is a potent dual IDO1 (uncompetitive, Ki of 0.23 μM) and TDO (competitive, Ki of 0.73 μM) inhibitor. IDO1/TDO-IN-1 (30) significantly promotes cell apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway[1]. | [IC 50]
IDO1: 0.23 μM (Ki); TDO: 0.73 μM (Ki) | [References]
[1] Jiangxin Liu, et al. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. Eur J Med Chem. 2022 May 5;235:114294. DOI:10.1016/j.ejmech.2022.114294 |
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