Nur77 antagonist 1(Compound ja) (10 mg/kg, i.p) has excellent antitumor efficiency and good in vivo tolerance in the breast cancer MDA-MB-231 xenograft nude mice model[1].
Nur77 antagonist 1 (1.25-5 μM) has good in vivo safety in zebrafish embryo model[1].
Animal Model: | the breast cancer MDA-MB-231 xenograft nude mice model[1] |
Dosage: | 10 mg/kg |
Administration: | i.p |
Result: | Reduced tumor weight and volume with tumor growth inhibition (TGI) of 99.95%.
Increased cleaved caspase 3 and decreased the proliferation marker Ki67 expression in tumor tissues.
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