| Identification | Back Directory | [Name]
Acetamide, 2-amino-N-[[(7S)-7-ethyl-7,8,11,13-tetrahydro-7-hydroxy-8,11-dioxo-10H-1,3-dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14-yl]methyl]- | [CAS]
2378427-68-8 | [Synonyms]
Acetamide, 2-amino-N-[[(7S)-7-ethyl-7,8,11,13-tetrahydro-7-hydroxy-8,11-dioxo-10H-1,3-dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-14-yl]methyl]- | [Molecular Formula]
C24H22N4O7 | [MOL File]
2378427-68-8.mol | [Molecular Weight]
478.45 |
| Chemical Properties | Back Directory | [Boiling point ]
976.8±65.0 °C(Predicted) | [density ]
1.62±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
11.17±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Gly-7-MAD-MDCPT (compound 4b) is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin (HY-16560) compound, it shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM[1]. Gly-7-MAD-MDCPT (0.1-1000 nM) shows cytotoxic potency to 786-0, BxPC3, HL-60 and SK-MEL-5 with IC50 values of 100-1000 nM[1].
Gly-7-MAD-MDCPT (0.1-1000 nM) shows cytotoxic potency to L540cy, MM.1R, M0LM13, Ramos, SK-MEL-5, SU-DHL-4 and U266 with IC50 values of 10-100 nM[1]. | [Uses]
Gly-7-MAD-MDCPT (compound 4b) is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin.html" class="link-product" target="_blank">Camptothecin (HY-16560) compound, it shows cytotoxicity to various cancer cells with IC50 values of 10-1000 nM[1]. | [storage]
Store at -20°C | [References]
[1] Jeffrey Scott, et al. Preparation of camptothecin peptide conjugates as antitumor agents. WO2019195665. 2019 10-10. |
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