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ChemicalBook--->CAS DataBase List--->2378384-49-5

2378384-49-5

2378384-49-5 Structure

2378384-49-5 Structure
IdentificationBack Directory
[Name]

(S)-CE-123
[CAS]

2378384-49-5
[Synonyms]

(S)-CE-123
Hazard InformationBack Directory
[Uses]

(S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC50 of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals[1][2].
[in vivo]

(S)-CE-123 (6.0, 12.0, 24.0 mg/kg; ip; 30 min before testing) significantly attenuates the effects of TBZ (Tetrabenazine; HY-B0590) on lever pressing and chow intake. (S)-CE-123 alone has no significant difference with vehicle-treated rats[1].

Animal Model:Trained rats (adult male Sprague-Dawley rats)[1]
Dosage:6.0, 12.0, 24.0 mg/kg
Administration:IP; 30 min before testing
Result:Attenuated the effects of TBZ (1.0 mg/kg) on lever pressing and chow intake.
[References]

[1] Renee A Rotolo, et al. The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. Front Pharmacol. 2019 Jun 28:10:682. DOI:10.3389/fphar.2019.00682
[2] Eduardo R. Perez Gonzalez, et al. Process Development and Scale-Up of a Novel Atypical DAT Inhibitor (S)-CE-123. ACS Omega 2024, March 4.
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