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Lanreotide (BIM 23014) acetate is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for the research of carcinoid syndrome[1][2]. | [in vivo]
Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition[1]. | Animal Model: | Male nude mice, 8 weeks old and 20–25?g in body weight (GH3 tumor-bearing nude mice)[1] | | Dosage: | 2.5, 5, 10?mg/kg | | Administration: | Subcutaneous; daily for 5 days | | Result: | Produced tumor growth inhibition. |
| [References]
[1] Ning S, et al. Lanreotide promotes apoptosis and is not radioprotective in GH3 cells.Endocr Relat Cancer.?2009 Sep;16(3):1045-55. DOI:10.1677/ERC-09-0003
[2] Florio T, et al. Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.Clin Endocrinol (Oxf).?2003 Jul;59(1):115-28. DOI:10.1046/j.1365-2265.2003.01811.x |
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