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ChemicalBook--->CAS DataBase List--->2376127-86-3

2376127-86-3

2376127-86-3 Structure

2376127-86-3 Structure
IdentificationBack Directory
[Name]

SN-38-CM2
[CAS]

2376127-86-3
[Synonyms]

SN-38-CM2
Hazard InformationBack Directory
[Uses]

SN-38-CM2 is a split esterase, and shows >95% conversion to SN-38 within 5 min in vitro. SN-38-CM2 induces protein-protein interactions (PPI)-dependent esterase to mediate cell death in MDA-MB-231 cells[1].
[References]

[1] Jones KA, et al. Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation. ACS Cent Sci. 2019 Nov 27;5(11):1768-1776. DOI:10.1021/acscentsci.9b00567
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