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ChemicalBook--->CAS DataBase List--->2375541-73-2

2375541-73-2

2375541-73-2 Structure

2375541-73-2 Structure
IdentificationBack Directory
[Name]

Autogramin-1
[CAS]

2375541-73-2
[Synonyms]

Autogramin-1
Inhibitor,inhibit,Autogramin1,Autogramin-1,Autophagy,Autogramin 1
tert-butyl 2-(2,4-dioxo-3-propyl-1,2,3,4-tetrahydroquinazoline-7-carboxamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
Thiazolo[5,4-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-2-[[(1,2,3,4-tetrahydro-2,4-dioxo-3-propyl-7-quinazolinyl)carbonyl]amino]-, 1,1-dimethylethyl ester
[Molecular Formula]

C23H27N5O5S
[MOL File]

2375541-73-2.mol
[Molecular Weight]

485.56
Chemical PropertiesBack Directory
[density ]

1.359±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

6.67±0.20(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM)[1].
[References]

[1] Laraia L, et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat Chem Biol. 2019 Jul;15(7):710-720. DOI:10.1038/s41589-019-0307-5
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