| Identification | Back Directory | [Name]
Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- | [CAS]
2375420-34-9 | [Synonyms]
SR-717 free acid
2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoic acid
Benzoic acid, 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]- | [Molecular Formula]
C15H9F2N5O3 | [MDL Number]
MFCD34470849 | [MOL File]
2375420-34-9.mol | [Molecular Weight]
345.26 |
| Hazard Information | Back Directory | [Uses]
SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1]. | [in vivo]
SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT or Stinggt/gt mice[1].
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming[1]. | Animal Model: | WT or Stinggt/gt mice[1] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneally; once-per-day for 1 week | | Result: | Maximally inhibited tumor growth. |
| [References]
[1] Emily N Chin, et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. 2020 Aug 21;369(6506):993-999. DOI:10.1126/science.abb4255 |
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