| Identification | Back Directory | [Name]
STAT3-IN-3 | [CAS]
2361304-26-7 | [Synonyms]
STAT3-IN-3
STAT3 inhibitor 3
2H-1-Benzopyran-2-one, 3-[[4-[(4-bromo-1,1-dioxidobenzo[b]thien-2-yl)carbonyl]-1-piperazinyl]carbonyl]-7-(diethylamino)- | [Molecular Formula]
C27H26BrN3O6S | [MOL File]
2361304-26-7.mol | [Molecular Weight]
600.48 |
| Chemical Properties | Back Directory | [Boiling point ]
915.1±65.0 °C(Predicted) | [density ]
1.572±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (8.33 mM) | [form ]
Solid | [pka]
3.19±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research[1]. | [Biological Activity]
STAT3-IN-3 is a potent and selective STAT3 inhibitor with antiproliferative activity. It can induce apoptosis in breast cancer cells. It is a promising mitochondria-targeted STAT3 inhibitor for cancer research. | [in vivo]
STAT3-IN-3 (10mg/kg-20 mg/kg; ip; daily; for 14 days) possesses potent antitumor activity against implanted 4T1 breast tumors growth.
| Animal Model: | Adult female BALB/c mice (6 weeks of age) | | Dosage: | 10 mg/kg, 20 mg/kg | | Administration: | Intraperitoneal injection, daily, for 14 days | | Result: | Significantly inhibited tumor volume. | | [target]
| [IC 50]
STAT3 | [storage]
Store at -20°C | [References]
[1] Cai G, et al. Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors. Eur J Med Chem. 2019 Jul 15;174:236-251. DOI:10.1016/j.ejmech.2019.04.024 |
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|