Identification | Back Directory | [Name]
N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,3-dimethylphenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | [CAS]
2361139-70-8 | [Synonyms]
RIPK3-IN-1 N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-2,3-dimethylphenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide 3-Pyridinecarboxamide, N-[4-[[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-2,3-dimethylphenyl]-1-(4-fluorophenyl)-1,2-dihydro-2-oxo- | [Molecular Formula]
C29H25FN4O4 | [MDL Number]
MFCD32671300 | [MOL File]
2361139-70-8.mol | [Molecular Weight]
512.53 |
Chemical Properties | Back Directory | [Boiling point ]
774.9±60.0 °C(Predicted) | [density ]
1.406±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 5 mg/mL (9.76 mM; ultrasonic and warming and heat to 80°C) | [form ]
Solid | [pka]
11.44±0.70(Predicted) | [color ]
Light yellow to yellow |
Hazard Information | Back Directory | [Uses]
RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM[1]. | [IC 50]
RIPK3: 9.1 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Amy C Hart, et al. Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage. ACS Med Chem Lett. 2019 May 6;11(3):266-271. DOI:10.1021/acsmedchemlett.9b00065 |
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