Chemical Properties | Back Directory | [Boiling point ]
727.1±60.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
11.95±0.46(Predicted) |
Hazard Information | Back Directory | [Description]
TCO-PEG8-TFP ester is a monodisperse crosslinker containing a TCO moiety and an PFP ester. The hydrophilic PEG8 arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label amine-containing antibodies, proteins and other macromolecules with TCO moiety. The PFP ester is amine-reactive, stable compound. PFP esters are less susceptible toward hydrolysis compared to NHS esters. | [Uses]
TCO-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|