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ChemicalBook--->CAS DataBase List--->2353410-06-5

2353410-06-5

2353410-06-5 Structure

2353410-06-5 Structure
IdentificationBack Directory
[Name]

TCO-PEG8-TFP ester
[CAS]

2353410-06-5
[Synonyms]

TCO-PEG8-TFP ester
[Molecular Formula]

C34H51F4NO12
[MDL Number]

MFCD31811550
[MOL File]

2353410-06-5.mol
[Molecular Weight]

741.76
Chemical PropertiesBack Directory
[Boiling point ]

727.1±60.0 °C(Predicted)
[density ]

1.23±0.1 g/cm3(Predicted)
[solubility ]

Soluble in DMSO, DCM, DMF
[pka]

11.95±0.46(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard InformationBack Directory
[Description]

TCO-PEG8-TFP ester is a monodisperse crosslinker containing a TCO moiety and an PFP ester. The hydrophilic PEG8 arm increases water-solubility and decreases steric hindrance during ligation. This reagent can be used to label amine-containing antibodies, proteins and other macromolecules with TCO moiety. The PFP ester is amine-reactive, stable compound. PFP esters are less susceptible toward hydrolysis compared to NHS esters.
[Uses]

TCO-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs; Alkyl/ether
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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