| Identification | Back Directory | [Name]
IV-23 | [CAS]
2326007-49-0 | [Synonyms]
IV-23
IV23,IV 23
Methanone, (5-bromo-2,3-dihydro-1H-indol-1-yl)(3,4,5-trimethoxyphenyl)- | [Molecular Formula]
C18H18BrNO4 | [MDL Number]
MFCD32201099 | [MOL File]
2326007-49-0.mol | [Molecular Weight]
392.24 |
| Hazard Information | Back Directory | [Uses]
IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC)[1]. | [References]
[1] Fu DJ, et al. Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis. Bioorg Chem. 2019 Aug 10;92:103190. DOI:10.1016/j.bioorg.2019.103190 |
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