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ChemicalBook--->CAS DataBase List--->2326007-49-0

2326007-49-0

2326007-49-0 Structure

2326007-49-0 Structure
IdentificationBack Directory
[Name]

IV-23
[CAS]

2326007-49-0
[Synonyms]

IV-23
IV23,IV 23
Methanone, (5-bromo-2,3-dihydro-1H-indol-1-yl)(3,4,5-trimethoxyphenyl)-
[Molecular Formula]

C18H18BrNO4
[MDL Number]

MFCD32201099
[MOL File]

2326007-49-0.mol
[Molecular Weight]

392.24
Chemical PropertiesBack Directory
[Boiling point ]

543.3±50.0 °C(Predicted)
[density ]

1.427±0.06 g/cm3(Predicted)
[pka]

-1.85±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC)[1].
[References]

[1] Fu DJ, et al. Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis. Bioorg Chem. 2019 Aug 10;92:103190. DOI:10.1016/j.bioorg.2019.103190
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