Identification | Back Directory | [Name]
FK-788 | [CAS]
227951-89-5 | [Synonyms]
FK-788 Acetic acid, 2-[[(6R)-6-[[[(diphenylamino)carbonyl]oxy]methyl]-5,6,7,8-tetrahydro-6-hydroxy-1-naphthalenyl]oxy]- | [Molecular Formula]
C26H25NO6 | [MDL Number]
MFCD32204701 | [MOL File]
227951-89-5.mol | [Molecular Weight]
447.48 |
Hazard Information | Back Directory | [Uses]
FK-788 is a PGI(2) and IP agonist with a strong anti-aggregation effect, with an IC50 of 18 nM and a high binding affinity for the human recombinant IP receptor, with a Ki value of 20 nM[1][2]. | [References]
[1] Kouji Hattori, et al. Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3091-5. DOI:10.1016/j.bmcl.2005.04.047 [2] Fujiko Takamura, et al. Metabolism investigation leading to novel drug design 2: orally active prostacyclin mimetics. Part 5. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4475-8. DOI:10.1016/j.bmcl.2006.06.033 |
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