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ChemicalBook--->CAS DataBase List--->227002-04-2

227002-04-2

227002-04-2 Structure

227002-04-2 Structure
IdentificationBack Directory
[Name]

Quinoxaline, 2-chloro-3-[(phenylsulfonyl)methyl]-
[CAS]

227002-04-2
[Synonyms]

L764406
L-764406
L 764406
Quinoxaline, 2-chloro-3-[(phenylsulfonyl)methyl]-
[Molecular Formula]

C15H11ClN2O2S
[MOL File]

227002-04-2.mol
[Molecular Weight]

318.78
Chemical PropertiesBack Directory
[Boiling point ]

510.5±50.0 °C(Predicted)
[density ]

1.420±0.06 g/cm3(Predicted)
[pka]

-3.81±0.48(Predicted)
Hazard InformationBack Directory
[Description]

L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma.
[Uses]

L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs[1].
[References]

[1] L-764406 Is a Partial Agonist of Human Peroxisome Proliferator-activated Receptor g
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