| Identification | Back Directory | [Name]
metipranolol | [CAS]
22664-55-7 | [Synonyms]
Disorat
Glausyn
Glauline
VUFB-6453
Methypranol
Trimepranol
4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)-2,3,6-TRIMETHYLPHENYL ACETATE
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethylphenol 1-acetate
Phenol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethyl-, 1-acetate | [EINECS(EC#)]
245-151-5 | [Molecular Formula]
C17H27NO4 | [MDL Number]
MFCD00864567 | [MOL File]
22664-55-7.mol | [Molecular Weight]
309.4 |
| Chemical Properties | Back Directory | [Melting point ]
105-107℃ | [Boiling point ]
458.7±45.0 °C(Predicted) | [density ]
1.068 | [storage temp. ]
4°C, protect from light | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
13.91±0.20(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3 | [InChIKey]
BQIPXWYNLPYNHW-UHFFFAOYSA-N | [SMILES]
C1(OC(=O)C)=C(C)C=C(OCC(O)CNC(C)C)C(C)=C1C |
| Hazard Information | Back Directory | [Uses]
Antihypertensive (β-blocker, ophthalmic). | [Definition]
ChEBI: 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angl
glaucoma. | [Brand name]
OptiPranolol (Bausch
& Lomb Pharmaceuticals). | [in vivo]
At postnatal day 35 (P35), rd10 mice given daily subcutaneous injections of 40 mg/kg of Metipranolol has reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer thickness, and substantially more staining for rhodopsin. At P50, Metipranolol-treated rd10 mice has decreased 3-nitrotyrosine staining in the retina, increased immunostaining for cone arrestin, a marker for cone photoreceptors, and significantly higher scotopic and photopic b-wave amplitudes at the highest stimulus intensity. At P65, cone density is significantly higher in Metipranolol-treated versus vehicle-injected rd10 mice[1]. | [IC 50]
β1 adrenoceptor: 8.3 (pA2); β2 adrenoceptor: 8.4 (pA2) | [storage]
4°C, protect from light |
|
| Company Name: |
ChemeGen Gold
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
|