| Identification | Back Directory | [Name]
RWJ-445167 | [CAS]
226566-43-4 | [Synonyms]
3DP-10017
RWJ-445167
1(2H)-Pyridineacetamide, N-[2-[[(aminoiminomethyl)amino]oxy]ethyl]-6-methyl-3-[[(3-methylphenyl)sulfonyl]amino]-2-oxo- | [Molecular Formula]
C18H24N6O5S | [MDL Number]
MFCD30532546 | [MOL File]
226566-43-4.mol | [Molecular Weight]
436.49 |
| Hazard Information | Back Directory | [Uses]
RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity. | [References]
[1] RWJ-445167, et al. Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa. Chem Biol Drug Des. 2006 Jul;68(1):29-36. DOI:10.1111/j.1747-0285.2006.00408.x |
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