| Identification | Back Directory | [Name]
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester | [CAS]
2252422-32-3 | [Synonyms]
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 17-(2,5-dioxo-1-pyrrolidinyl) ester | [Molecular Formula]
C26H38N2O10 | [MOL File]
2252422-32-3.mol | [Molecular Weight]
538.59 |
| Chemical Properties | Back Directory | [density ]
1.28±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [pka]
12.05±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
endo-BCN-PEG4-NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The BCN group enables copper free click chemistry with azide-tagged biomolecules. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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