| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2245842-16-2 | [Synonyms]
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite
2’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-2’-fluoroinosine3’-CEDphosphoramidite
5’-O-(4,4-Dimethoxytrityl)-2’-fluoro-2’-deoxy inosine-3’-CED phosphoramidite
2’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-2’-fluoro inosine 3’-CED phosphoramidite
5'-O-(4，4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyinosine-3'-cyanoethyl phosphoramidite
(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluoro-5-(6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite | [Molecular Formula]
C40H46FN6O7P | [MDL Number]
MFCD22374068 | [MOL File]
2245842-16-2.mol | [Molecular Weight]
772.82 |
| Hazard Information | Back Directory | [Uses]
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia[1][2]. | [References]
[1] Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107. DOI:10.1096/fj.00-0299com
[2] Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. DOI:10.1203/00006450-198802000-00001 |
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