| Identification | Back Directory | [Name]
Azidoethyl-SS-propionic NHS ester | [CAS]
2243566-44-9 | [Synonyms]
Azidoethyl-SS-propionic NHS ester | [Molecular Formula]
C9H12N4O4S2 | [MDL Number]
MFCD31693737 | [MOL File]
2243566-44-9.mol | [Molecular Weight]
304.34 |
| Hazard Information | Back Directory | [Description]
Azidoethyl-SS-propionic NHS ester is a Click Chemistry crosslinker. The azide group enables Click Chemistry reactions with alkynes, DBCO and BCN. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The disulfide bond can be cleaved by Dithiothreitol (DTT) reagent | [Uses]
Azidoethyl-SS-propionic NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azidoethyl-SS-propionic NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Disulfide Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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