| Identification | Back Directory | [Name]
6H-Purin-6-one, 2-amino-8-[1-(21-chloro-3,6,9,12,15-pentaoxaheneicos-1-yl)-1H-pyrazol-4-yl]-9-[(4-fluorophenyl)methyl]-1,9-dihydro- | [CAS]
2241668-58-4 | [Synonyms]
6H-Purin-6-one, 2-amino-8-[1-(21-chloro-3,6,9,12,15-pentaoxaheneicos-1-yl)-1H-pyrazol-4-yl]-9-[(4-fluorophenyl)methyl]-1,9-dihydro- | [MOL File]
2241668-58-4.mol | [Molecular Weight]
664.17 |
| Hazard Information | Back Directory | [Uses]
2G-HaloAUTAC (Compound tt44) is a second-generation autophagy-targeting chimera (2G-HaloAUTAC) that improves the activity of AUTACs by replacing the L-Cysteine ??(L-Cys) linker with other structures. 2G-HaloAUTAC exhibits degradation activity against EGFP-HaloTag protein through an autophagic mechanism[1]. | [References]
[1] Takahashi D, et al., Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66(17):12342-12372. DOI:10.1021/acs.jmedchem.3c00861 |
|
|