| Identification | Back Directory | [Name]
Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- | [CAS]
2231760-33-9 | [Synonyms]
Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- | [Molecular Formula]
C20H23N3O2S | [MDL Number]
MFCD34469346 | [MOL File]
2231760-33-9.mol | [Molecular Weight]
369.48 |
| Chemical Properties | Back Directory | [density ]
1.314±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (135.33 mM; Need ultrasonic) | [form ]
Solid | [pka]
9.49±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PI3Kγ inhibitor AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). PI3Kγ inhibitor AZ2 can be used for the research of inflammatory and immune diseases[1]. | [Biological Activity]
AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). AZ2 can be used for the research of inflammatory and immune diseases[1].
AZ2 (0.1~100 nM; 1 hour; SKOV-3 cells) excellent selectivity for PI3Kγ is further confirmed with a constitutively activated PI3K/Akt pathway[1]. | [IC 50]
PI3Kγ: 9.3 (pIC50); PI3Kδ: 6.6 (pIC50); PI3Kα: 5.1 (pIC50); PI3Kβ: 4.5 (pIC50) | [References]
[1]. Gangadhara G, et al. A class of highly selective inhibitors bind to an active state of PI3Kγ. Nat Chem Biol. 2019;15(4):348-357. |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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