| Identification | Back Directory | [Name]
β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- | [CAS]
2225940-46-3 | [Synonyms]
Pomalidomide-C2-acid
N-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]-b-alanine
3-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]propanoic acid
3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propanoic acid
β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- | [Molecular Formula]
C16H15N3O6 | [MDL Number]
MFCD32898771 | [MOL File]
2225940-46-3.mol | [Molecular Weight]
345.31 |
| Chemical Properties | Back Directory | [Boiling point ]
708.5±60.0 °C(Predicted) | [density ]
1.578±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.42±0.10(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-C2-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [References]
[1] Md Kabir, et al. Discovery and Characterization of a Novel Cereblon-Recruiting PRC1 Bridged PROTAC Degrader. J Med Chem. 2024 Apr 25;67(8):6880-6892. DOI:10.1021/acs.jmedchem.4c00538 |
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