2222280-83-1

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2222280-83-1 Structure

Identification	Back Directory
[Name] SHP504
[CAS] 2222280-83-1
[Synonyms] SHP504 3-[4-(2-Chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-4-hydroxybenzoic Acid Benzoic acid, 3-[4-[(2-chlorophenyl)methyl]-4,5-dihydro-5-oxo[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-4-hydroxy-
[Molecular Formula] C23H15ClN4O4
[MOL File] 2222280-83-1.mol
[Molecular Weight] 446.84

Hazard Information	Back Directory
[Uses] SHP504 is a SHP2 phosphatase inhibitor, with an IC50 of 21 μM for SHP21–525[1].
[References] [1] Michelle Fodor, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem Biol. 2018 Mar 16;13(3):647-656. DOI:10.1021/acschembio.7b00980

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