Identification | Back Directory | [Name]
5-chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide | [CAS]
22203-98-1 | [Synonyms]
3',5-dichlorosalicylanilide 5-chloro-N-(3-chlorophenyl)-2-hydroxy-benzamide Benzamide, 5-chloro-N-(3-chlorophenyl)-2-hydroxy- | [Molecular Formula]
C13H9Cl2NO2 | [MOL File]
22203-98-1.mol | [Molecular Weight]
282.12 |
Hazard Information | Back Directory | [Uses]
SARS-CoV-2-IN-14 (compound 6) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.39 μM. SARS-CoV-2-IN-14 is a niclosamide analogue. SARS-CoV-2-IN-14 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1]. | [References]
[1] Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295. DOI:10.1016/j.ejmech.2022.114295 |
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