| Identification | Back Directory | [Name]
4H-1,3-Benzothiazin-4-one, 8-nitro-6-(trifluoromethyl)-2-[4-[[4-(trifluoromethyl)-1-piperidinyl]methyl]-1-piperidinyl]- | [CAS]
2219325-28-5 | [Synonyms]
Tuberculosis inhibitor 3
4H-1,3-Benzothiazin-4-one, 8-nitro-6-(trifluoromethyl)-2-[4-[[4-(trifluoromethyl)-1-piperidinyl]methyl]-1-piperidinyl]- | [Molecular Formula]
C21H22F6N4O3S | [MOL File]
2219325-28-5.mol | [Molecular Weight]
524.48 |
| Chemical Properties | Back Directory | [Boiling point ]
552.6±60.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 27.5 mg/mL (52.43 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.18±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against agent-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability[1]. | [Biological Activity]
Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against drug-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability[1].
Tuberculosis inhibitor 3 (compound 2i, 50 mg/kg) shows acceptable PK properties with the AUC of 2489 h?ng/mL) is. The Tmax of Tuberculosis inhibitor 3 is 0.25 h[1]. | [storage]
Store at -20°C | [References]
[1]. Kai Lv, et al. Design, synthesis and antitubercular evaluation of benzothiazinones containing a piperidine moiety. Eur J Med Chem. 2018 May 10;151:1-8. |
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