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ChemicalBook--->CAS DataBase List--->2217671-41-3

2217671-41-3

2217671-41-3 Structure

2217671-41-3 Structure
IdentificationBack Directory
[Name]

2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-
[CAS]

2217671-41-3
[Synonyms]

POLA1 inhibitor 1
2-Propenoic acid, 3-[4'-hydroxy-2-[(hydroxyimino)methyl]-3'-tricyclo[3.3.1.13,7]dec-1-yl[1,1'-biphenyl]-4-yl]-, (2E)-
[Molecular Formula]

C26H27NO4
[MOL File]

2217671-41-3.mol
[Molecular Weight]

417.5
Chemical PropertiesBack Directory
[Boiling point ]

643.1±55.0 °C(Predicted)
[density ]

1.35±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

-95.65±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].
[in vivo]

POLA1 inhibitor 1 (Compound 12) (15 mg/kg and 50 mg/kg) displays a significantly antitumor effect in HT-29 and MM487 xenografts[1].

[References]

[1] Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253. DOI:10.1016/j.bioorg.2020.104253
2217671-41-3 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Website: http://www.cw-bio.com
Company Name: Nantong Hanfang Biotechnology Co. , Ltd.  
Tel: hanfangpharma@126.com; 18616537568
Website: https://hanfangpharma@126.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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