| Identification | Back Directory | [Name]
1H-Indole, 2-(2,6-dimethyl-4-pyridinyl)-3-(1-methylethyl)-5-(4-piperidinyl)- | [CAS]
2205846-49-5 | [Synonyms]
BMS-905
1H-Indole, 2-(2,6-dimethyl-4-pyridinyl)-3-(1-methylethyl)-5-(4-piperidinyl)- | [Molecular Formula]
C23H29N3 | [MOL File]
2205846-49-5.mol | [Molecular Weight]
347.5 |
| Chemical Properties | Back Directory | [Boiling point ]
522.8±50.0 °C(Predicted) | [density ]
1.085±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
15.38±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
BMS-905 is a Dual Antagonist of Toll-like Receptors 7 and 8 (TLR7/8) | [Uses]
BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC50s: 0.7 and 3.2 nM respectively). BMS905 inhibits TLR7 or TLR8 induced IL-6 production in human/mouse whole blood. BMS905 can be used for research of lupus[1]. | [References]
[1] Sreekantha RK, et al. Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8). ACS Med Chem Lett. 2022 Apr 25;13(5):812-818. DOI:10.1021/acsmedchemlett.2c00049 |
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