| Identification | Back Directory | [Name]
Spiro[1-azabicyclo[2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridine], (2'R)- | [CAS]
220099-91-2 | [Synonyms]
AZD 0328
220099-91-2
UNII-2B218X5QIY
(2R)-3H-1'-Azaspiro[furo[2,3-b]pyridine-2,3'-bicyclo[2.2.2]octane
(2R)-Spiro[1-azabicyclo[2.2.2]octane-3,2(3H)-furo[2,3-b]pyridine]
Spiro[1-azabicyclo[2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridine], (2'R)-
(R)-6',7'-dihydro-3'H-4-azaspiro[bicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine | [Molecular Formula]
C13H16N2O | [MOL File]
220099-91-2.mol | [Molecular Weight]
216.28 |
| Hazard Information | Back Directory | [Uses]
AZD0328 is a selective α7 nAChR partial agonist. AZD0328 selectively enhances midbrain dopaminergic neuronal activity and enhances cortical dopamine levels in rats. AZD0328 improves cognitive performance[1][2]. | [References]
[1] Sydserff S, et al. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. DOI:10.1016/j.bcp.2009.07.005
[2] Castner SA, et al. Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors. Biol Psychiatry. 2011 Jan 1;69(1):12-8. DOI:10.1016/j.biopsych.2010.08.006 |
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