Identification | Back Directory | [Name]
N-phenyl-N-methylglycine hydrochloride | [CAS]
21911-75-1 | [Synonyms]
N-phenyl-N-methylglycine hydrochloride 2-(N-methylanilino)aceticacid,hydrochloride [Methyl(phenyl)amino]acetic acid hydrochloride | [Molecular Formula]
C9H12ClNO2 | [MDL Number]
MFCD13186269 | [MOL File]
21911-75-1.mol | [Molecular Weight]
202 |
Chemical Properties | Back Directory | [Melting point ]
214-215 °C(Solv: hydrochloric acid (7647-01-0)) | [storage temp. ]
Inert atmosphere,Room Temperature | [Appearance]
White to off-white Solid |
Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of N-phenyl-N-methylglycine hydrochloride from methyl 2-(methyl(phenyl)amino)acetate:
c) Preparation of N-phenyl-N-methylglycine hydrochloride
Methyl 2-(methyl(phenyl)amino)acetate (0.80 g, 4.46 mmol) obtained from step b was dissolved in 10% aqueous hydrochloric acid (20 mL) and the reaction was stirred under reflux conditions for 4 hours. After completion of the reaction, water was removed by distillation under reduced pressure and the resulting residue was dried under vacuum to give the crude product (0.81 g) as a solid. The crude product was washed with acetone and again dried under vacuum to give purified N-phenyl-N-methylglycine hydrochloride (0.65 g, 72% yield).
Product characterization data: 1H NMR (400 MHz, DMSO-d6) δ: 7.15 (m, 2H), 6.65 (m, 3H), 4.08 (s, 2H), 3.71 (s, 3H), 2.96 (s, 3H). | [References]
[1] Patent: US2005/107355, 2005, A1. Location in patent: Page/Page column 29-30 |
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Cool Pharm, Ltd
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Energy Chemical
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