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ChemicalBook--->CAS DataBase List--->2157482-40-9

2157482-40-9

2157482-40-9 Structure

2157482-40-9 Structure
IdentificationBack Directory
[Name]

FGFR1 inhibitor-11
[CAS]

2157482-40-9
[Synonyms]

FGFR1 inhibitor-11
[Molecular Formula]

C23H18O4
[MOL File]

2157482-40-9.mol
[Molecular Weight]

358.39
Chemical PropertiesBack Directory
[Boiling point ]

550.5±50.0 °C(predicted)
[density ]

1.289±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

9.95±0.30(predicted)
Hazard InformationBack Directory
[Uses]

FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity[1].
[in vivo]

FGFR1 inhibitor-11 (15-30 mg/kg; p.o.; 2 times per day) significantly preventes bone loss (BV, T-BMD, etc.) in mice[1].

[References]

[1] Zhihao Chen, et al. Discovery of a novel homoisoflavonoid derivative 5g for anti-osteoclastic bone loss via targeting FGFR1. Eur J Med Chem. 2024 Mar 27:270:116335. DOI:10.1016/j.ejmech.2024.116335
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