| Hazard Information | Back Directory | [Uses]
Zalifrelimab (AGEN1884) is a fully human IgG1 monoclonal antibody targeting CTLA-4 (CTLA-4). Zalifrelimab antagonizes the inhibitory checkpoints of immune cell activation regulated by CTLA-4 signaling[1]. | [in vivo]
Zalifrelimab (AGEN1884; 10 mg/kg; i.v.; on days 1 and 29) is well-tolerated in non-human primates and enhances vaccine-mediated antigen-specific immunity[2]. | Animal Model: | Cynomolgus macaques (Macaca fascicularis)[2] | | Dosage: | 10 mg/kg | | Administration: | i.v.; on days 1 and 29 | | Result: | Enhanced antigen-specific immune responses in combination with reporter vaccines in vivo. |
| [References]
[1] David M O'Malley, et al. Dual PD-1 and CTLA-4 Checkpoint Blockade Using Balstilimab and Zalifrelimab Combination as Second-Line Treatment for Advanced Cervical Cancer: An Open-Label Phase II Study. J Clin Oncol. 2022 Mar 1;40(7):762-771. DOI:10.1200/JCO.21.02067
[2] Randi B Gombos, et al. Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody. PLoS One. 2018 Apr 4;13(4):e0191926. DOI:10.1371/journal.pone.0191926 |
|
| Company Name: |
Biolab Reagents
|
| Tel: |
18108604356 18108604356 |
| Website: |
www.biolabreagent.com/ |
|