31374-18-2

2148-57-4

The general procedure for the synthesis of 4,7-dichloroquinazoline from 7-chloro-4(3H)-quinazolinone was as follows: 7-chloro-3H-quinazolin-4-one (170, 0.155 g, 0.85830 mmol) was dissolved in a screw cap vial containing 1 mL of phosphorus oxychloride (POCl3). After sealing the vial, the reaction was placed in an oil bath at 100 °C for 3 hours. Upon completion of the reaction, the resulting solution was concentrated under vacuum and distilled three times by azeotropic distillation with toluene to completely remove the residual phosphorous trichloride, resulting in the target compound 4,7-dichloroquinazoline (171, 0.162 g, 0.81391 mmol, 94.828% yield). The mass spectrometry analysis showed m/z 199.0 ([M+H]+).