Identification | Back Directory | [Name]
Propanamide, N-(4,10-dihydro-5,5-dioxido-10-oxothieno[3,2-c][1]benzothiepin-9-yl)-3,3,3-trifluoro-2-hydroxy-2-methyl-, (2S)- | [CAS]
214764-26-8 | [Synonyms]
KW7158 KW-7158 KW 7158 Propanamide, N-(4,10-dihydro-5,5-dioxido-10-oxothieno[3,2-c][1]benzothiepin-9-yl)-3,3,3-trifluoro-2-hydroxy-2-methyl-, (2S)- | [Molecular Formula]
C16H12F3NO5S2 | [MOL File]
214764-26-8.mol | [Molecular Weight]
419.4 |
Hazard Information | Back Directory | [Uses]
KW-7158 is a putative afferent nerve inhibitor that can depress vesica-vascular reflexes in rats. KW-7158 is an inhibitor of nucleoside transporter-1 (ENT1/SLC29A1) and acts as an antagonist for overactive bladder (OAB)[1][2]. | [References]
[1] Nishiya Y, et al. The anti-overactive bladder activity of KW-7158 is mediated by blocking equilibrative nucleoside transporter-1. Biol Pharm Bull. 2014;37(1):130-6. DOI:10.1248/bpb.b13-00658 [2] Shing-Hwa Lu, et al. Effect of KW-7158, a putative afferent nerve inhibitor, on bladder and vesico-vascular reflexes in rats. Brain Res. 2002 Aug 9;946(1):72-8. DOI:10.1016/s0006-8993(02)02828-7 |
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