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ChemicalBook--->CAS DataBase List--->214764-26-8

214764-26-8

214764-26-8 Structure

214764-26-8 Structure
IdentificationBack Directory
[Name]

Propanamide, N-(4,10-dihydro-5,5-dioxido-10-oxothieno[3,2-c][1]benzothiepin-9-yl)-3,3,3-trifluoro-2-hydroxy-2-methyl-, (2S)-
[CAS]

214764-26-8
[Synonyms]

KW7158
KW-7158
KW 7158
Propanamide, N-(4,10-dihydro-5,5-dioxido-10-oxothieno[3,2-c][1]benzothiepin-9-yl)-3,3,3-trifluoro-2-hydroxy-2-methyl-, (2S)-
[Molecular Formula]

C16H12F3NO5S2
[MOL File]

214764-26-8.mol
[Molecular Weight]

419.4
Chemical PropertiesBack Directory
[Boiling point ]

718.3±60.0 °C(Predicted)
[density ]

1.635±0.06 g/cm3(Predicted)
[pka]

10.40±0.29(Predicted)
Hazard InformationBack Directory
[Uses]

KW-7158 is a putative afferent nerve inhibitor that can depress vesica-vascular reflexes in rats. KW-7158 is an inhibitor of nucleoside transporter-1 (ENT1/SLC29A1) and acts as an antagonist for overactive bladder (OAB)[1][2].
[References]

[1] Nishiya Y, et al. The anti-overactive bladder activity of KW-7158 is mediated by blocking equilibrative nucleoside transporter-1. Biol Pharm Bull. 2014;37(1):130-6. DOI:10.1248/bpb.b13-00658
[2] Shing-Hwa Lu, et al. Effect of KW-7158, a putative afferent nerve inhibitor, on bladder and vesico-vascular reflexes in rats. Brain Res. 2002 Aug 9;946(1):72-8. DOI:10.1016/s0006-8993(02)02828-7
214764-26-8 suppliers list
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