| Identification | Back Directory | [Name]
AZD5991 | [CAS]
2143010-83-5 | [Synonyms]
AZD5991
AZD-5991 Racemate
22H-9,4,8-(Metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid, 5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl- | [Molecular Formula]
C35H34ClN5O3S2 | [MDL Number]
MFCD31807622 | [MOL File]
2143010-83-5.mol | [Molecular Weight]
672.26 |
| Chemical Properties | Back Directory | [Boiling point ]
949.6±65.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO |
| Hazard Information | Back Directory | [Uses]
AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a Mcl-1 inhibitor with an IC50 of <3 nM in FRET assay. | [IC 50]
Mcl-1: 3 nM (IC50) | [References]
[1] Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9(1):5341. DOI:10.1038/s41467-018-07551-w |
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