858600-08-5

75-16-1

213193-32-9

Step 2: Amide (10.4 g, 53 mmol) was dissolved in tetrahydrofuran (THF, 100 mL) and the solution was cooled to 0°C. Methylmagnesium bromide (3M ether solution, 26.5 mL) was added slowly and dropwise at 0 °C. After the dropwise addition was completed, the reaction mixture was kept at 0°C and continued to be stirred for 1 hour. Subsequently, the reaction was quenched slowly with 1 M hydrochloric acid (aqueous solution). The mixture was extracted with ethyl acetate (EtOAc) and the organic layers were combined. The organic layer was washed with saturated brine and dried with anhydrous magnesium sulfate (MgSO4). After filtration to remove the drying agent, the filtrate was concentrated under reduced pressure to give 7.8 g of 5-acetyl-2-methoxypyridine in the form of a colorless solid in 97% yield.