| Identification | Back Directory | [Name]
YW1128 | [CAS]
2131223-64-6 | [Synonyms]
YW1128
YW1128,YW-1128
3-triazole-4-carboxamide
5-methyl-1-(2-methylphenyl)-N-2-quinolinyl-1H-1
5-METHYL-1-(2-METHYLPHENYL)-N-2-QUINOLINYL-1H-1;2;3-TRIAZOLE-4-CARBOXAMIDE
1H-1,2,3-Triazole-4-carboxamide, 5-methyl-1-(2-methylphenyl)-N-2-quinolinyl- | [Molecular Formula]
C20H17N5O | [MOL File]
2131223-64-6.mol | [Molecular Weight]
343.38 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30mg/mL; DMSO: 30mg/mL; Ethanol: 30mg/mL; PBS (pH 7.2): 2mg/mL | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay. It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks. | [Uses]
YW1128 (compound 3a) is a potent Wnt/β-Catenin inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism[1]. | [storage]
Store at -20°C | [References]
[1] Obianom ON, et al. Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice. J Med Chem. 2019 Jan 24;62(2):727-741. DOI:10.1021/acs.jmedchem.8b01408 |
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| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
www.biorbyt.com |
|