| Identification | Back Directory | [Name]
NOCISTATIN (HUMAN) | [CAS]
212609-11-5 | [Synonyms]
NOCISTATIN (HUMAN)
MET-PRO-ARG-VAL-ARG-SER-LEU-PHE-GLN-GLU-GLN-GLU-GLU-PRO-GLU-PRO-GLY-MET-GLU-GLU-ALA-GLY-GLU-MET-GLU-GLN-LYS-GLN-LEU-GLN
L-Glutamine, L-methionyl-L-prolyl-L-arginyl-L-valyl-L-arginyl-L-seryl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-α-glutamyl-L-prolyl-L-α-glutamyl-L-prolylglycyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-alanylglycyl-L-α-glutamyl-L-methionyl-L-α-glutamyl-L-glutaminyl-... | [Molecular Formula]
C149H238N42O53S3 | [MDL Number]
MFCD01867731 | [MOL File]
212609-11-5.mol | [Molecular Weight]
3561.93 |
| Chemical Properties | Back Directory | [density ]
1.54±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [Sequence]
Met-Pro-Arg-Val-Arg-Ser-Leu-Phe-Gln-Glu-Gln-Glu-Glu-Pro-Glu-Pro-Gly-Met-Glu-Glu-Ala-Gly-Glu-Met-Glu-Gln-Lys-Gln-Leu-Gln |
| Hazard Information | Back Directory | [Uses]
Nocistatin (human) blocks nociceptin-induced allodynia and hyperalgesia, and attenuates pain evoked by prostaglandin E2[1]. | [References]
[1] E Okuda-Ashitaka, et al. Nocistatin, a peptide that blocks nociceptin action in pain transmission. Nature. 1998 Mar 19;392(6673):286-9. DOI:10.1038/32660
[2] M Hiramatsu, et al. Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice. Eur J Pharmacol. 1999 Feb 19;367(2-3):151-5. DOI:10.1016/s0014-2999(99)00003-5 |
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