| Identification | Back Directory | [Name]
LONAPRISAN | [CAS]
211254-73-8 | [Synonyms]
ZK 230211
ZK 232011
LONAPRISAN
ZK230211;ZK-230211;ZK 230211
19-Norpregna-4,9-dien-3-one, 11-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-, (11β,17α)-
(8S,11R,13S,14S,17S)-11-(4-acetylphenyl)-17-hydroxy-13-methyl-17-(1,1,2,2,2-pentafluoroethyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one | [Molecular Formula]
C28H29F5O3 | [MDL Number]
MFCD22572768 | [MOL File]
211254-73-8.mol | [Molecular Weight]
508.53 |
| Hazard Information | Back Directory | [Uses]
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect[1]. | [References]
[1] Fuhrmann U, et al., Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem. 2000 Dec 28;43(26):5010-6. DOI:10.1021/jm001000c |
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