| Identification | Back Directory | [Name]
3(R)-HYDROXYMETHYLMORPHOLINE | [CAS]
211053-49-5 | [Synonyms]
(R)-3-Morpholinemethanol
(3R)-3-Morpholinemethanol
(R)-morpholin-3-ylmethanol
(3R)-morpholine-3-methanol
3-MorpholineMethanol, (3R)-
3(R)-HYDROXYMETHYLMORPHOLINE
((3R)-Morpholin-3-yl)methanol
(R)-3-Hydroxymethylmorpholine
3(R)-HYDROXYMETHYLMORPHOLINE HCL,
(3R)-3-Morpholinemethanol,99%e.e.
(3R)-Morpholin-3-ylMethanol hydrochloride
3(R)-Hydroxymethylmorpholine hydrochloride | [Molecular Formula]
C5H11NO2 | [MDL Number]
MFCD06799479 | [MOL File]
211053-49-5.mol | [Molecular Weight]
117.15 |
| Chemical Properties | Back Directory | [Melting point ]
78-81°C | [Boiling point ]
218℃ | [density ]
1.045 | [Fp ]
86℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform | [form ]
Solid | [pka]
14.85±0.10(Predicted) | [color ]
White to Off-White | [Optical Rotation]
Consistent with structure |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
A chiral morpholine drivative | [Uses]
A chiral morpholine drivative. | [Synthesis]
General procedure for the synthesis of (R)-3-hydroxymethylmorpholine from (R)-(4-benzyl-3-morpholinyl)-methanol:
(a) Preparation of (3R)-morpholin-3-ylmethanol: [(3R)-4-benzylmorpholin-3-yl]methanol (cf. J. Med. Chem.; 29; 1986; 1288-1290; 1.1 g, 5.4 mmol) was dissolved in ethanol (25 mL), palladium hydroxide (20% loaded on activated carbon, 0.7 g) and acetic acid (0.5 mL). The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (1.2 bar). After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by evaporation under reduced pressure. The residue except 200 mg was dissolved in ether (1 mL) and tetrahydrofuran (10 mL). The solution was purified by passing it through a strong cation exchange column (Isolute SCX-2, 10 g). The column was first washed with tetrahydrofuran, followed by elution of the target product with ammonia-saturated methanol. The solvent was removed by evaporation under reduced pressure to give 0.3625 g (57% yield) of (3R)-morpholin-3-ylmethanol as an oil.1H NMR (500 MHz, CD3OD): δ 2.9 (m, 3H), 3.3 (t, 1H), 3.5 (m, 3H), 3.7-3.9 (m, 2H). | [References]
[1] Patent: WO2006/137790, 2006, A1. Location in patent: Page/Page column 35
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2227 - 2244 |
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