| Identification | Back Directory | [Name]
BAY707) | [CAS]
2109805-96-9 | [Synonyms]
BAY707)
BAY-707
(BAY 707
BAY-707 free base
1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]- | [Molecular Formula]
C15H20N4O2 | [MDL Number]
MFCD31814430 | [MOL File]
2109805-96-9.mol | [Molecular Weight]
288.34 |
| Chemical Properties | Back Directory | [density ]
1.225±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:28.83(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:2.88(Max Conc. mg/mL);10.0(Max Conc. mM) | [form ]
Solid | [pka]
14.36±0.40(Predicted) | [color ]
Light yellow to khaki |
| Hazard Information | Back Directory | [Uses]
BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy[1]. | [Biological Activity]
BAY-707 is a substrate-competitive, highly selective inhibitor of MTH1(NUDT1) with IC50 of 2.3 nM. It has a favorable pharmacokinetic profile compared to other MTH1 compounds and is well tolerated in mice, but the experiments clearly lack in vitro or in vivo anticancer efficacy. | [in vivo]
Bay-077 (orally adminstation; 50-250 mg/kg; 2 weeks) exhibits superior biochemical potency, cellular target engagement, and a pharmacokinetic profile to other MTH1 tool compounds, But Bay-077 exerts no anticancer efficacy either in mono- or in combination therapies in CT26 and NCI-H460 mice model. | [target]
IC50: 2.3 nM (MTH1/NUDT1) | [storage]
Store at -20°C | [References]
[1] Ellermann M, et al. Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. DOI:10.1021/acschembio.7b00370 |
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Merck KGaA
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