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ChemicalBook--->CAS DataBase List--->210825-31-3

210825-31-3

210825-31-3 Structure

210825-31-3 Structure
IdentificationBack Directory
[Name]

CP-424,174
[CAS]

210825-31-3
[Synonyms]

CP-424,174
CP-424,174 >=98% (HPLC)
N-((4-Chloro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide
CP424174,IL-1β,NLRP3,Inhibitor,CP 424174,CP-424174,Inflammasome,inhibit,NOD-like Receptor (NLR)
N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Benzenesulfonamide, N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)-
[Molecular Formula]

C22H29ClN2O4S
[MDL Number]

MFCD30537538
[MOL File]

210825-31-3.mol
[Molecular Weight]

452.99
Chemical PropertiesBack Directory
[density ]

1?+-.0.06 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:5): 0.16 mg/ml
[form ]

powder
[pka]

4.67±0.10(Predicted)
[color ]

white to beige
Hazard InformationBack Directory
[Uses]

CP-424174 is a reversible inhibitor against IL-1β processing with an IC50 of 210 nM.CP-424174 indirectly inhibits NLRP3[1].
[Biochem/physiol Actions]

CP-424,174 is a cytokine release inhibitory drugs (CRID) that inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes. It is quite possible that similarly to CP-456,773 (termed CRID3), CP-424,174 inhibits both NLRP3 and AIM2 inflammasomes by preventing ASC oligomerisation.
[References]

[1] Alex G Baldwin, et al. Inhibiting the Inflammasome: A Chemical Perspective. J Med Chem DOI:10.1021/acs.jmedchem.5b01091
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