| Identification | Back Directory | [Name]
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 | [CAS]
2107273-56-1 | [Synonyms]
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 | [Molecular Formula]
C46H68ClN5O10 | [MDL Number]
MFCD29764359 | [MOL File]
2107273-56-1.mol | [Molecular Weight]
886.53 |
| Hazard Information | Back Directory | [Description]
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG linker containing a cyanine dye with excitation/emmission maximum 649/667 nm as well as an azide group, which enables Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media. | [Uses]
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Alfa Chemistry
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1-516-6625404 |
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https://www.alfa-chemistry.com |
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