| Identification | Back Directory | [Name]
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 | [CAS]
2107273-38-9 | [Synonyms]
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 | [Molecular Formula]
C42H62ClN5O8 | [MDL Number]
MFCD30536178 | [MOL File]
2107273-38-9.mol | [Molecular Weight]
800.44 |
| Hazard Information | Back Directory | [Description]
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a PEG linker containing cyanine dye with excitation/emmission maximum 555/570 nm as well as an azide group, which enables Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media. | [Uses]
N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(m-PEG4)-N'-(azide-PEG4)-Cy3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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