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ChemicalBook--->CAS DataBase List--->2101305-84-2

2101305-84-2

2101305-84-2 Structure

2101305-84-2 Structure
IdentificationBack Directory
[Name]

GSK690
[CAS]

2101305-84-2
[Synonyms]

GSK690
[Molecular Formula]

C24H23N3O
[MOL File]

2101305-84-2.mol
[Molecular Weight]

369.46
Chemical PropertiesBack Directory
[Boiling point ]

530.5±50.0 °C(Predicted)
[density ]

1.21±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

powder
[pka]

9.91±0.10(Predicted)
[color ]

white to beige
Hazard InformationBack Directory
[Description]

GSK-690 is a potent and selective Reversible Inhibitors of Lysine Specific Demethylase 1.
[Uses]

GSK 690 is a reversible inhibitor of lysine specific demethylase 1 (LSD1), with a Kd value of 9 nM and a biochemical IC50 of 37 nM.
[References]

[1] Mould DP, et al. Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2017 Oct 12;60(19):7984-7999. DOI:10.1021/acs.jmedchem.7b00462
[2] Haydn T, et al. Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells. Cell Death Dis. 2017 Jun 15;8(6):e2879. DOI:10.1038/cddis.2017.239
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