| Identification | Back Directory | [Name]
N-(Boc-PEG1)-N-bis(PEG2-propargyl) | [CAS]
2100306-63-4 | [Synonyms]
N-(Boc-PEG1)-N-bis(PEG2-propargyl)
5,11,14-Trioxa-2,8-diazaheptadec-16-ynoic acid, 8-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C23H40N2O7 | [MDL Number]
MFCD30723238 | [MOL File]
2100306-63-4.mol | [Molecular Weight]
456.57 |
| Chemical Properties | Back Directory | [Boiling point ]
535.4±50.0 °C(Predicted) | [density ]
1.068±0.06 g/cm3(Predicted) | [form ]
Viscous Liquid | [pka]
12.26±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a click chemistry branched linker. The propargyl groups can react with azide-bearing molecule via copper catalyzed Click Chemistry . The Boc group can be deprotected under acidic conditions to release amine group. | [Uses]
N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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