| Identification | Back Directory | [Name]
Propargyl-PEG5-CH2CO2tBu | [CAS]
2098489-63-3 | [Synonyms]
Propargyl-PEG4-O-C1-Boc
Propargyl-PEG5-CH2COOtBu
Propargyl-PEG5-CH2CO2tBu
Propargyl-PEG5-CH2COOH t-Bu Ester
3,6,9,12,15-Pentaoxaoctadec-17-ynoic acid, 1,1-dimethylethyl ester | [Molecular Formula]
C17H30O7 | [MDL Number]
MFCD31580155 | [MOL File]
2098489-63-3.mol | [Molecular Weight]
346.42 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG5-CH2CO2tBu enables the formation of triazole linkages with azide compounds or biomolecules in copper catalyzed Click Chemistry reactions. The t-butyl group can be hydrolyzed under acidic conditions. | [Uses]
Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-O-C1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781 |
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